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SIGIRR (single immunoglobulin and toll-interleukin 1 receptor (TIR) domain) Blocking Peptide (100ug)

SIGIRR (single immunoglobulin and toll-interleukin 1 receptor (TIR) domain) Blocking Peptide (100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-SIGIRR antibody (Catalogue #: ARP49664_P050) made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Presku: AAP49664
Size: 100 ug
Weight: 25kDa
Gene: 59307
Format: Lyophilized powder
Target: SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.
Alternative names: MGC110992; TIR8
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