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SH3BP2 (Human) cDNA (1ug)

SH3BP2 (Human) cDNA (1ug)

Supplier: Aviva Systems Biology Incorporated
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The ORF of human SH3BP2 is amplified by PCR using a high fidelity enzyme and sub-cloned into a Prokaryotic expression vector under the control of the tac promoter. The expression of the gene has been confirmed by Western blot using an anti-SH3BP2 polyclonal antibody.
Presku: ANA10217
Size: 1ug
Gene: 6452
Target: The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
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