Rubella Grade IV Antigen (HPV77) Protein (1mg)

Grade IV - PBS
Viral Strain: HPV77 Propagated in Vero Cells UV Inactivated

Introduction: Rubella (German Measles) Virus Antigen is medically significant because of its teratogenic effect when contracted by childbearing women. Maternal infection, especially during the first trimester of pregnancy, can result in a range of congenital birth defects including deafness, cataracts, diabetes and cardiac and bone abnormalities. The characteristic multi-system defects resulting from a Rubella prenatal infection are termed the Congenital Rubella Syndrome (CRS).
Serologic tests are an important aid in the prevention of prenatal Rubella infections. The incidence of this disease has decreased dramatically in the United States following the nationwide Rubella testing and immunization program.
Rubella Virus Antigen is prepared by the concentration of cell culture fluid from cells infected with Rubella Virus strain HPV77. The Rubella virus is purified by gradient centrifugation and yields an antigen high in sensitivity with low backgrounds in the ELISA and other solid phase immunoassays. The Rubella Grade IV product #6076 and #6123 are ~90% pure and are typically required for IgM antibody testing. All of the Rubella products are inactivated and are tested for infectivity prior to release.

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