
Supplier:
Aviva Systems Biology IncorporatedRRP8 (ribosomal RNA processing 8, methyltransferase, homolog (yeast) ) Blocking Peptide (the N terminal of RRP8)(100ug)
Prices direct from Aviva Systems Biology Incorporated
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SPECIFICATIONS
Size
100ug
Reactivities
Hum
Format
Lyophilized powder
Presku
AAP68567
Target
RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Weight
50kDa
Gene Id
23378
Alternative Names
KIAA0409
Applications
ELISA, WB
Hosts
Mouse
Applications
IHC
Hosts
Mouse
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