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RIC8A (resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)) Blocking Peptide (the N terminal of RIC8A)(100ug)

RIC8A (resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)) Blocking Peptide (the N terminal of RIC8A)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-RIC8A Antibody(ARP57567_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Human
Presku: AAP57567
Size: 100ug
Weight: 60kDa
Gene: 60626
Format: Lyophilized powder
Target: RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. RIC8A also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Alternative names: MGC104517; MGC131931; MGC148073; MGC148074; RIC8; synembryn
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