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RIC8A (resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)) Blocking Peptide (the N terminal of RIC8A)(100ug)

RIC8A (resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)) Blocking Peptide (the N terminal of RIC8A)(100ug)

This is a synthetic peptide designed for use in combination with anti-RIC8A Antibody(ARP57567_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.

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SPECIFICATIONS

Size

100ug

Reactivities

Hum

Format

Lyophilized powder

Presku

AAP57567

Target

RIC8A is a guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins.RIC8A is able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.RIC8A is involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. RIC8A also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Weight

60kDa

Gene Id

60626

Alternative Names

MGC104517; MGC131931; MGC148073; MGC148074; RIC8; synembryn

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