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Rhodopsin Antibody
ABBIOTEC

Supplier:

ABBIOTEC

Cat no: 253211

Rhodopsin Antibody

Rhodopsin is a photoreceptor protein found in retinal rods. It is a comple, Xenopus/Amphibian, formed by the binding of retinaldehyde, the o, Xenopus/Amphibian,idized form of retinol, to the protein opsin and undergoes a series of comple, Xenopus/Amphibian, reactions in response to visible light resulting in the transmission of nerve impulses to the brain. Mutation of the rhodopsin gene is a major contributor to various retinopathies such as retinitis pigmentosa. The disease-causing protein generally aggregates with ubiquitin in inclusion bodies, disrupts the intermediate filament network and impairs the ability of the cell to degrade non-functioning proteins which leads to photoreceptor apoptosis. Other mutations on rhodopsin lead to , Xenopus/Amphibian,-linked congenital stationary night blindness,Mouse,ainly due to constitutive activation, when the mutations occur around the chromophore binding pocket of rhodopsin. Several other pathological states relating to rhodopsin have been discovered including poor post-Golgi trafficking, dysregulative activation, rod outer segment instability and arrestin binding.

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SPECIFICATIONS

Catalog Number

253211

Size

0.1 ml

Applications

IHC

Reactivities

Hum, Mouse, Rabbit

Format

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of HEPES (pH7.5), 0.01% BSA, with 50% glycerol. Antibody was purified by Protein-G affinity chromatography.

P Type

Mouse Monoclonal Antibody

Antigen

Bovine rhodopsin.

Isotype

Mouse IgG1

Accession

P02699

Clonality

1D4

Additional Info

Rhodopsin; RHO

SUPPLIER INFO

ABBIOTEC

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