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Rest (RE1-silencing transcription factor ) Blocking Peptide (the middle region of Rest)(100ug)

Rest (RE1-silencing transcription factor ) Blocking Peptide (the middle region of Rest)(100ug)

Supplier: Aviva Systems Biology Incorporated
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This is a synthetic peptide designed for use in combination with anti-Rest Antibody (ARP38643_P050), made by Aviva Systems Biology. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications. Please inquire for more details.
Reactivities: Mouse
Presku: AAP38643
Size: 100ug
Weight: 118kDa
Gene: The peptide is characterized by mass spectroscopy
Format: Lyophilized powder
Target: Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Alternative names: 2610008J04Rik; AA407358; MGC150099; NRSF
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