Vascular Endothelial Growth Factor-A (VEGF-A) was originally isolated from tumor cells and is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability, VEGF-A may play a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several variants, VEGF-165 being the most abundant. and bovine VEGF are one amino acid shorter than the factor, and the bovine and sequences show a homology of 95%. Recombinant VEGF-165 is a non-glycosylated, disulfide-linked homodimer, containing 165 amino acids, with a molecular weight of 39 kDa.