Vascular Endothelial Growth Factor-A (VEGF-A) was originally isolated from tumor cells and is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability, VEGF-A may play a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several variants, one being VEGF-121. and bovine VEGF are one amino acid shorter than the factor, and the bovine and sequences show a homology of 95%. Recombinant VEGF-121 is a non-glycosylated homodimer, containing two 121 amino acid chains, with a total molecular weight of 28.4 kDa.
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