Recombinant mouse IL-12 (p70) (carrier-free)

IL12 (p70) is a disulfide-linked heterodimer composed of unrelated p40 (glycosylated) and p35 subunits. IL-12 acts as a growth factor for activated human T and NK cells, enhance the lytic activity of human NK cells, and stimulate the production of IFNg, by resting human PBMC. IL-12R is formed by two chains, IL-12Rbeta1 and IL-12Rbeta2. IL-12Rbeta1 is associated with the Janus kinase (Jak) Tyk2 and binds IL-12 p40; IL-12Rbeta2 is associated with Jak2 and binds either the heterodimer or the p35 chain. Signaling through the IL-12 receptor complex induces phosphorylation, dimerization, and nuclear translocation of several signal transducer and activator of transcription (STAT) family members (STAT1, 3, 4, 5), but most of the biological responses to IL-12 have been attributed to STAT4.

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SPECIFICATIONS

Catalog Number

577004

Size

25 microg

Gene Id

16159,16160

Storage Temp

-20 C or -70 C

Shipping Temp

Blue Ice

Storage Buffer

Unopened vial can be stored at -20C for six months or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in buffer containing carrier protein such as 1% BSA or HSA or 10% FBS. For long term-storage, aliquot into polypropylene vials and store in a manual defrost freezer. Avoid repeated freeze/thaw cycles.

Alternative Names

Interleukin-12 p70, p40 and p35 cystine linked subunits, CLMF, NKSF, TcMF, TSF

Regulatory Status

RUO