Recombinant Mouse CXCL17 (VCC-1) (carrier-free)

CXCL17 is the latest identified member of the CXC chemokine family and may contribute to tumor angiogenesis and progression. Ectopic expression of human CXCL17 in HUVEC significantly upregulated the RNA level of genes involved in angiogenesis including VEGF-A and basic FGF. NIH3T3 cells overexpressing human or mouse CXCL17 developed rapid growing tumors in mice. In vitro chemotaxis assay shows that human CXCL17 can induce migration of CD14+ monocytes and CD11c+ immature dendritic cells from human peripheral blood, and mouse CXCL17 can induce CD11b+Gr1highF4/80− cells from mouse spleen cells. CXCL17 also shows broad antimicrobial activity by disrupting bacterial membrane. High levels of CXCL17 have been detected in bronchoalveolar lavage fluid of patients with idiopathic pulmonary fibrosis.

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SPECIFICATIONS

Catalog Number

585406

Size

100 microg

Gene Id

232983

Storage Temp

-20 C or -70 C

Shipping Temp

Blue Ice

Storage Buffer

Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1% BSA or HSA. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.

Alternative Names

VEGF co-regulated chemokine 1 (VCC-1, VCC1), dendritic cell- and monocyte-attracting chemokine-like protein (DMC)

Regulatory Status

RUO