Recombinant Mouse CXCL1 (KC) (carrier-free)

The CXCL1/KC gene was initially identified as being regulated by PDGF in BALB/c-3T3 cells. CXCL1/KC is an ELR CXC chemokine, and it is structurally and functionally related to the human GROs (CXCL1-CXCL3) and interleukin-8 (CXCL8). CXCL1, CXCL2, and CXCL3 bind to the CXCR2 receptor, with CXCL1 having the highest affinity. CXCL1 is crucial for the recruitment of neutrophils to inflammatory sites. In addition, CXCL1 has pleiotropic effects on cell proliferation, tumor angiogenesis, invasion, and metastasis. CXCL1 and CXCL2 induce neutrophil mobilization from the bone marrow in a murine model of acute peritonitis, and CXCL1 and G-CSF act cooperatively in this process. In addition, CXCL1 mediates murine sickle cell vasoocclusion during hemolytic transfusion reactions. Thrombin enhances the secretion of CXCL1 from tumor cells, and PGE2 stimulates expression of CXCL1 in human colorectal carcinoma cells (CRC). Furthermore, CXCL1 (secreted by CRC cells) induces endothelial cell migration and tube formation in vitro and in vivo. CXCL1 is induced by inflammatory cytokines such as IL-1 and TNF, and IL-17A enhances expression of CXCL1 by prolonging the half-life of its constitutively unstable mRNA.

Prices direct from BioLegend

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

573702

Size

10 microg

Gene Id

14825

Storage Temp

-20 C or -70 C

Shipping Temp

Blue Ice

Storage Buffer

Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in buffer containing carrier protein such as 1% BSA or HSA or 10% FBS. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.

Alternative Names

KC, secreted protein N51, FSP, Grow regulated oncogen 1 (GRO1), Grow regulated oncogen a (GRO a), melanoma growth stimulating activity (MGSA), MGSA-a, neutrophil activating protein 3 (NAP-3), SCYB1

Regulatory Status

RUO