Recombinant Mouse CCL20 (MIP-3alpha) (carrier-free)

CCL20 is an inflammatory cytokine involved in the recruitment of leukocytes to sites of injury and inflammation. CCL20 is expressed at a low basal level, but it is induced by proinflammatory cytokines and Toll-like receptor (TLR) agonists. During infections, CCL20 expression is stimulated in epithelial cells, and immature CCR6+ dendritic cells (DCs) are recruited. Thereafter, CCR6 is downregulated during DC maturation, and the DCs migrates to the lymph node under the expression of CCR7. CCL20 is the only ligand for CCR6. Nevertheless, mouse and human beta-defensin-1 and -2, small cationic antimicrobial peptides, bind and activate CCR6. Contrarily, these beta-defensins have lower affinities for CCR6 than CCL20. In fact, human CCL20 has potent antimicrobial activity.

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SPECIFICATIONS

Catalog Number

582304

Size

25 microg

Gene Id

20297

Storage Temp

-20 C or -70 C

Shipping Temp

Blue Ice

Storage Buffer

Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1% BSA or HSA. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.

Alternative Names

Macrophage inflammatory protein-3alpha (MIP-3alpha), Liver and activation-regulated chemokine (LARC), Exodus

Regulatory Status

RUO