Mig ion Inhibitory Factor (MIF) is a pro-inflammatory cytokine that acts on fibroblasts by inducing IL-1, IL-8 and MMP expression. MIF stimulates NO production and TNF- alpha release following IFN gamma -activation of macrophages. Recombinant MIF is a non-glycosylated Protein, containing 115 amino acids, with a molecular weight of 12.5 kDa