Interleukin 17F (IL-17F) is one of six members of the IL-17 family (IL-17A-F) secreted by activated CD4+ T cells and monocytes. Similar to IL-17A, IL-17F binds to the IL17 RC receptor and promotes the production of IL-6, IL-8, G-CSF and increases matrix turnover es. IL-17F is also thought to inhibit angiogenesis and induce endothelial cells to produce IL-2, MCP-1 and TGF- beta 1. Recombinant IL-17F is a non-glycosylated, disulfide-linked homodimer, containing two 134 amino acid chainss, with a total molecular weight of 30 kDa.
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