Insulin-like Growth Factor I, IGF-I, is a growth factor produced by the liver when stimulated with growth hormone and can be found circulating throughout the body. IGF-I activates the IGF-I receptor (IGF1R) and the insulin receptor to mediate growth of almost every cell of the body. IGF-I is known as one of the most potent activators of the AKT signaling pathway which is known to be a stimulator of prolife ion and an inhibitor of programmed cell death. Mature IGF-I is 100% homologous with bovine and porcine Proteins. Recombinant IGF-I is a non-glycosylated Protein, containing 70 amino acids, with a molecular weight of 7.7 kDa.
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