Recombinant Human LT-alpha (TNF-beta)

LT-alpha, also known as TNF-beta, is a potent mediator of inflammatory and immune responses. It belongs to the TNF superfamily of ligands and signals through TNFR1 and TNFR2. LT-alpha is produced by activated T and B lymphocytes, and has similar activities to TNF-alpha. Like TNF-alpha, LT-alpha (TNF-beta) is involved in the regulation of various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. LT-alpha is secreted as a soluble polypeptide, but can form heterotrimers with LT-beta, which effectively anchors the LT-alpha to the cell surface. LT-alpha is cytotoxic to a wide range of tumor cells. Recombinant human LT-alpha is secreted 171 amino acid protein (18.6 kD) which forms an active non-disulfide linked homotrimer structure in solution.

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SPECIFICATIONS

Catalog Number

562603

Size

5 microg

Applications

ELISA

Gene Id

4049

Dilutions

Each lot of this protein is quality control tested by ELISA assay. For use as an ELISA standard, a standard curve comprised of doubling dilutions from 2000 pg/ml to 16 pg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Shipping Temp

Ambient RT

Storage Buffer

The lyophilized protein is stable for at least 2 years from date of receipt at -20C. Reconstituted LT-alpha is stable for at least 3 months when stored in working aliquots with a carrier protein at -20C. Avoid repeated freeze/thaw cycles.

Alternative Names

Tumor necrosis factor-beta, Lymphotoxin-alpha (LT- alpha), Coley

Regulatory Status

RUO