Recombinant Human IL-4 (carrier-free)

IL-4 is the primary cytokine implicated in the development of Th2-mediated responses, which is associated with allergy and asthma. The Type I receptor comprises IL-4Ralpha and the common gamma-chain (gammac), which is also shared by the cytokines IL-2, -7, -9, -15 and -21 and is present in hematopoietic cells. IL-4 can use the type II complex, comprising IL-4Ralpha and IL-13Ralpha1, which is present in non-hematopoietic cells. This second receptor complex is a functional receptor for IL-13, which shares approximately 25% homology with IL-4. The type I receptor complex can be formed only by IL-4 and is active in Th2 development. In contrast, the type II receptor complex formed by either IL-4 or IL-13 is most active during airway hypersensitivity and mucus secretion and is not found in T cells.

Prices direct from BioLegend

Quick response times

Exclusive Absave savings/discounts

SPECIFICATIONS

Catalog Number

574002

Size

10 microg

Gene Id

3565

Storage Temp

-20 C or -70 C

Shipping Temp

Blue Ice

Storage Buffer

Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. After dilution, the cytokine could be storage at 4C for one month and up to 3 months from -20C to -70C. Avoid repeated freeze/thaw cycles.

Alternative Names

Interleukin-4, IaIF, BSF-1, HCGF, MCGF-2, MFF, TCGF-2

Regulatory Status

RUO