Recombinant Human CCL26 (Eotaxin-3) (carrier-free)

Human CCL26 was identified by analysis of the genomic region containing the gene for CCL24. These two chemokines are localized within a region of ~40 kilobases. CCL26 is an agonist for CCR3 and is an antagonist for CCR1, CCR2, and CCR5. In addition to CCL11, CCL24, and CCL26, other chemokines bind to the CCR3 receptor such as CCL5, CCL8, CCL7, and CCL17. CCL26 is induced by IL-4 and IL-13 in human endothelial cells, and it induces eosinophil transmigration. CCL26 is stored in endothelial cell specific-storage granules (Weibel-Palade bodies) and is released upon secretogenic stimuli. Interestingly, CCL26 binds to CX3CR1 and induces adhesion of CX3CR1-expressing cells to endothelium. CCL26 has been linked to allergic diseases, eosinophil esophagitis and atopic dermatitis. In addition, high level of CCL26 in blood and affected tissues has been associated with Churg-Strauss syndrome, which is characterized by eosinophilia in blood and affected tissues.

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SPECIFICATIONS

Catalog Number

585206

Size

100 microg

Gene Id

10344

Storage Temp

-20 C or -70 C

Shipping Temp

Blue Ice

Storage Buffer

Unopened vial can be stored at 4C for three months, at -20C for six months, or at -70C for one year. For maximum results, quick spin vial prior to opening. Stock solutions should be prepared at no less than 10 microg/mL in sterile buffer (PBS, HPBS, DPBS, and EBSS) containing carrier protein such as 1% BSA or HSA. After dilution, the cytokine can be stored at 4C for one month or from -20C to -70C for up to 3 months. Avoid repeated freeze/thaw cycles.

Alternative Names

Eotaxin3, SCYA26

Regulatory Status

RUO