Fibroblast Growth Factors (FGFs) are a 22 member family of Proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. Although the mechanism remains unclear, FGF-basic 154, also known as FGF-2, is a critical component in keeping embryonic stem cells undifferentiated in cell culture systems. Recombinant FGF-b 154 (FGF-2) is a nonglycosylated Protein, containing 154 amino acids, with a molecular weight of 17.2 kDa.
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