Fibroblast Growth Factors (FGFs) are a 22 member family of Proteins known to be involved in angiogenesis, wound healing and embryonic development. As a family, they bind to heparin and signal through four receptor tyrosine kinases called, FGFR1, 2, 3 and 4. FGF-21 is most closely related to FGF-19 and shows low binding to heparin and is highly diffusible. Recombinant FGF-21 is a non-glycosylated Protein, containing 182 amino acids, with a molecular weight of 19.5 kDa.
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