Supplier:
Aviva Systems Biology IncorporatedRbm8a (RNA binding motif protein 8A ) Blocking Peptide (the N terminal of Rbm8a)(100ug)
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SPECIFICATIONS
Size
100ug
Reactivities
Hum, Rat
Format
Lyophilized powder
Presku
AAP40575
Target
Rbm8a is a component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A interacts with PYM that function to enhance the translation of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex.
Weight
19kDa
Gene Id
295284
Alternative Names
Rbm8
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