Rat Anti- Mouse NKG2- A/C/E- UNLB(0.5 mg)

The monoclonal antibody 20d5 reacts with an epitope common to the NKG2A, NKG2C and NKG2E isoforms of the CD94/NKG2 heterodimer, a member of the c-type lectin family of inhibitory receptors. Mouse CD94/NKG2 is a natural killer (NK) cell receptor for the non-classical MHC class I molecule Qa- 1b.^{2, 3} NKG2 is expressed on NK cells, lymphokine-activated killer (LAK) T cells, and some CD8⁺ memory T cells. Two-color immunofluorescent staining with the 20d5 antibody reveals two distinct NKG2⁺ phenotypes within the NK1.1⁺CD3- spleen cell population: NKG2^hi (50%) and NKG2^low (50%). With the exception of DBA/2J mice, NKG2 is expressed on NK1.1⁺ cells from all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL).¹