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Rat Anti- Mouse MAdCAM- 1- UNLB(0.5 mg)

Rat Anti- Mouse MAdCAM- 1- UNLB(0.5 mg)

Mucosal vascular addressin-1 (MAdCAM-1) is a type I transmembrane glycoprotein expressed at high levels on high endothelial venules (HEV) of PeyerпїЅs patches and mesenteric lymph nodes, and on flatwalled venules within the gut lamina propria. It is also expressed on sinus-lining cells in the spleen.1-3 The countereceptor or пїЅhoming receptorпїЅ for MAdCAM-1 is alpha4beta7 integrin (also known as LPAM-1). MAdCAM-1 is also a facultative ligand for CD62L/L-selectin.4, 5 The monoclonal antibody MECA-367 binds to the first domain of MAdCAM-1 and blocks MAdCAM-1-dependent binding in vitro and lymphocyte homing to PeyerпїЅs patch HEV in vivo.1, 2, 4

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SPECIFICATIONS

Size

0.5 mg

Hosts

Rat

Clone

MECA- 367

Format

Purified (UNLB) Antibody

Presku

OASB00643

Isotype

IgG2a

SUPPLIER INFO

Aviva Systems Biology Incorporated

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