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Rat Anti- Mouse Ly- 6A/E- LE/AF(0.5 mg)

Rat Anti- Mouse Ly- 6A/E- LE/AF(0.5 mg)

Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins.1-3 It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes.4-6 In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes, whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes.1, 7-9 The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation.1, 8, 9 Studies with MAb D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses,9-12 and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.3, 13

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SPECIFICATIONS

Size

0.5 mg

Applications

FC

Hosts

Rat

Clone

D7

Format

Low Endotoxin, Azide- Free (LE/AF)

Presku

OASB00557

Isotype

IgG2a

SUPPLIER INFO

Aviva Systems Biology Incorporated

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