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Rat Anti- Mouse CD54/ICAM- 1- PE(0.1 mg)

Rat Anti- Mouse CD54/ICAM- 1- PE(0.1 mg)

CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN-gamma, IL-1, TNF-alpha, lipopolysaccharide and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.

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SPECIFICATIONS

Size

0.1 mg

Hosts

Rat

Clone

YN1/1.7.4

Format

R- phycoerythrin (R- PE) Conjugate

Presku

OASB00495

Isotype

IgG2b

SUPPLIER INFO

Aviva Systems Biology Incorporated

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