Rat Anti- Mouse CD49d/VLA- 4a- PE(0.2 mg)

VLA-4 belongs to the beta1-integrin family, which functions both as cell-matrix and cell-cell receptors.^1-3 As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1.^{1, 2} In addition to CD44/pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1.^{2, 3} CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive.^{1, 2} Antibody PS/2 also reacts with human VLA-4.¹