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Rat Anti- Mouse CD49d/VLA- 4a- PE(0.1 mg)

Rat Anti- Mouse CD49d/VLA- 4a- PE(0.1 mg)

VLA-4 belongs to the beta1-integrin family, which functions both as cell-matrix and cell-cell receptors.1-3 As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1.1, 2 In addition to CD44/pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1.2, 3 CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive.1, 2 Antibody PS/2 also reacts with human VLA-4.1

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SPECIFICATIONS

Size

0.1 mg

Applications

FC

Hosts

Rat

Clone

PS/2

Format

R- phycoerythrin (R- PE) Conjugate

Presku

OASB00238

Isotype

IgG2b

SUPPLIER INFO

Aviva Systems Biology Incorporated

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