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Rat Anti- Mouse CD4/L3T4- APC/CY5.5(0.1 mg)

Rat Anti- Mouse CD4/L3T4- APC/CY5.5(0.1 mg)

CD4/L3T4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested.1,2 CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors.3-5 The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells.1,2 In vivo and in vitro treatment with the GK1.5 mAb effectively depletes CD4+ cells.7,8 The mAb also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.1,8-13

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SPECIFICATIONS

Size

0.1 mg

Applications

FC

Hosts

Rat

Clone

GK1.5

Format

Allophycocyanin- Cyanine 5.5 (APC- CY 5.5) Conjugate

Presku

OASB00269

Isotype

IgG2b

SUPPLIER INFO

Aviva Systems Biology Incorporated

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