Rat Anti- Mouse CD24/HSA- FITC(0.5 mg)

CD24 is expressed in B cells until their terminal differentiation into plasma cells.¹ It has been used widely as a marker to fractionate different B-lineage differentiation stages.¹⁰ CD24 has been found on a variety of other hematopoietic and neural cell types, and is now classified as a costimulatory molecule.^2-4 The CD24/HSA molecule is composed mostly of carbohydrate, with a protein core of only 31-35 amino acids in the human and 27 amino acids in the mouse.^{1, 3} The molecular mass is variable, ranging from 38-70 kDa.3 CD24 is now included in the large group of phosphatidylinositol-anchored membrane proteins.^1-4 Studies with purified CD24 applied to latex beads have demonstrated a self-binding property, suggesting that the molecule is capable of promoting homotypic aggregation, binding and cell adhesion.³ This is supported by earlier observations of the blockade of B cell lymphoblast aggregation with anti- CD24 monoclonal antibody.⁶ Recent studies of murine CD24 have assigned a role for CD24/HSA as a ligand for P-selectin, a calcium-dependent lectin.⁷