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Rat Anti- Mouse CD22- SPRD(0.1 mg)

Rat Anti- Mouse CD22- SPRD(0.1 mg)

CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression.1, 2 CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion.2-4 Its intracellular domain is phosphorylated after antigen receptor crosslinking and is involved in negative regulation of B-cell activation.6-9

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SPECIFICATIONS

Size

0.1 mg

Applications

FC

Hosts

Rat

Clone

2D6

Format

SpectralRed (SPRD) Conjugate

Presku

OASB00368

Isotype

IgG1

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