Rat Anti- Mouse CD19- PE(0.2 mg)

CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220⁺/CD43⁺/HSa⁺) through fully differentiated B cell stages.^1-7 Terminally differentiated plasma cells do not express CD19.¹ In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation.^{3, 4} All splenic and peritoneal IgM⁺ cells of both B-1 and B-2 lineages are CD19⁺, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites.^{1, 7} Recent studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow.⁷ Monoclonal antibody 6D5 recognizes the same epitope as the published clone, 1D3.^{1, 8}