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Rat Anti- Mouse CD122- PE(0.1 mg)

Rat Anti- Mouse CD122- PE(0.1 mg)

The IL-2 receptor is a complex of three distinct polypeptide chains: (i) the alpha chain which binds IL-2 with low affinity; (ii) the beta chain that binds IL-2 with high affinity; and (ii) the common gamma chain (gammaC) that does not bind IL-2.2 The high affinity receptor complex is an alpha/beta/gamma heterotrimer with a Kd of 1.3 x 10-11 M.2 In mouse spleen, CD122 is expresed on ? 30% of CD8+ cells and all NK cells, but <1% of B cells and CD4+ T lymphocytes. In the thymus, its expression is confined to CD4-CD8+ single positive and CD4-CD8- double negative cells.4 Cytoplasmic regions of the IL-2R beta chain are involved in IL-2-mediated cellular signaling and, via the interaction of IL-2 and its receptor complex, may be involved in the generation and differentiation of T lymphocytes.1, 4 The monoclonal antibody 5H4 does not block IL-2 binding.1

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SPECIFICATIONS

Size

0.1 mg

Applications

FC

Hosts

Rat

Clone

5H4

Format

R- phycoerythrin (R- PE) Conjugate

Presku

OASB00699

Isotype

IgG2a

SUPPLIER INFO

Aviva Systems Biology Incorporated

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