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Rat anti- Human Caspase- 2- UNLB(0.1 mg)

Rat anti- Human Caspase- 2- UNLB(0.1 mg)

The Caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis2. Caspase 2 (ICH- 1/Nedd2) is an initiator caspase that is prevalent in both the cytosol and nucleus in many cell types3. During embryonic development it is expressed at relatively high levels in the central nervous system, liver, kidney and lungs and is prevalent in numerous tissues in adults4,5. Studies have shown that Caspase 2 becomes activated in response to several lethal stimuli including DNA damage, ER stress and death receptor stimulation and further evidence has suggested a role in reactive oxygen species-induced cell death2,6-9. The SB123a monoclonal antibody detects bands at ~40 and ~48 kD, corresponding to cleaved and uncleaved forms of Caspase 2, respectively.

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SPECIFICATIONS

Size

0.1 mg

Hosts

Rat

Clone

SB123a

Format

Purified (UNLB) Antibody

Presku

OASB01359

Isotype

IgM

SUPPLIER INFO

Aviva Systems Biology Incorporated

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