Rat anti- Human Caspase- 2- UNLB(0.1 mg)

The Caspases are a family of cysteine proteases that induce apoptosis in response to a variety of intra- and extracellular stimuli. These enzymes are synthesized as inactive precursors which become cleaved at aspartate-specific sites upon induction of apoptosis². Caspase 2 (ICH- 1/Nedd2) is an initiator caspase that is prevalent in both the cytosol and nucleus in many cell types³. During embryonic development it is expressed at relatively high levels in the central nervous system, liver, kidney and lungs and is prevalent in numerous tissues in adults^4,5. Studies have shown that Caspase 2 becomes activated in response to several lethal stimuli including DNA damage, ER stress and death receptor stimulation and further evidence has suggested a role in reactive oxygen species-induced cell death^2,6-9. The SB123a monoclonal antibody detects bands at ~40 and ~48 kD, corresponding to cleaved and uncleaved forms of Caspase 2, respectively.