Reactivities: | Human, Mouse |
Presku: | AAP59675 |
Size: | 100ug |
Weight: | 47kDa |
Gene: | 54354 |
Format: | Lyophilized powder |
Target: | Rassf5 is a potental tumor suppressor. It seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. It may be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis. |
Alternative names: | 1300019G20Rik; AU042887; Maxp1; Nore1; Nore1A; Nore1B; Rapl |