Reactivities: | Human |
Presku: | AAP43267 |
Size: | 100ug |
Weight: | 56kDa |
Gene: | 56852 |
Format: | Lyophilized powder |
Target: | RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, RAD18 is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. |
Alternative names: | RNF73 |