PYK2 (5E2D) Antibody

PYK2 (PTK2B protein tyrosine kinase 2 beta) is a cytoplasmic protein tyrosine kinase. It is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PYK2 may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flu, Xenopus/Amphibian, and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation,Mouse,embrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK and the SH2 domain of GRB2. This protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.

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SPECIFICATIONS

Catalog Number

252776

Size

0.1 ml

Applications

WB

Reactivities

Hum

Format

Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.

P Type

Mouse Monoclonal Antibody

Antigen

Purified recombinant fragment of PYK2(aa815-997) e, Xenopus/Amphibian,pressed in E. coli.\r<br>

Isotype

Mouse IgG2a

Accession

Q14289

Clonality

5E2D5

Additional Info

Protein-tyrosine kinase 2-beta; Calcium-dependent tyrosine kinase; CADTK; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; CAK-beta; CAKB; Focal adhesion kinase 2; FADK 2; Proline-rich tyrosine kinase 2; Related adhesion focal tyrosine kinase RAFTK; FAK2; PYK2; RAFTK ;PTK2B;