Purified anti-ZBP-1

Z-DNA binding protein 1 (ZBP-1) belongs to a family of proteins that contain the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RAN. Vertebrate ZBPs are induced by immunostimulation and are involved in host defense mechanisms. ZBP-1 initiates an innate immune response by binding to foreign DNA in the cytosol. ZBP-1 mediates activation of the innate immune system by facilitating DNA-mediated induction of type-1 IFN and expression of other related genes. Human ZBP-1 is most prominently expressed in lymphatic tissues. Besides its function in immunoresponse, it is up-regulated in mouse tumor stromal cells and is speculated to play a role in host defense again tumors.

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SPECIFICATIONS

Catalog Number

651601

Size

25 microg

Applications

FC, IF, IP, WB

Hosts

Rat

Reactivities

Hum

Clone

RonoB19

Antigen

Recombinant human ZBP-1, antibody recognizing Zbeta domain

Gene Id

81030

Isotype

Rat IgG2a, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

Z-DNA binding protein 1, Tumor stroma and activated macrophage protein DLM-1, DNA-dependent activator of interferon regulatory factors

Regulatory Status

RUO