Purified anti-XBP-1s

XBP-1 is a transcription factor containing a bZIP domain. It was first identified because of its binding ability to X-box, a conserved transcriptional element in the promoter of human HLA DR gene. XBP-1 has multiple functions. It controls MHC class II gene regulation and is also essential for differentiation of plasma cells. XBP-1 upregulates as part of the ER stress response, also known as the unfolded protein response. Unspliced XBP-1 is 261 amino acids and migrates on the SDS-PAGE around 33 kD; spliced XBP-1, recognized by clone 143F, is371 amino acids and migrates around 55 kD.\nп»ї

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SPECIFICATIONS

Catalog Number

647501

Size

25 microg

Applications

ELISA, IF, IHC, IP, WB

Hosts

Mouse

Reactivities

Hum

Clone

143F

Antigen

XBP-1s recombination protein

Gene Id

7494

Isotype

Mouse IgG2a

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1 to 2 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

X-box binding protein 1

Regulatory Status

RUO