Purified anti-VASP

VASP (vasodilator-stimulated phosphoprotein) is a 46 kD member of the Ena/VASP family that contains WH1, EVH1, and EVH2 domains as well as GPPPPP motifs. This protein forms tetramers and may act in concert with profilin to convey signal transduction to actin filament production. VASP is a crucial factor involved in enhancement of actin filament formation and has been shown to regulatee cell motility by controlling the geometry of actin filament networks within lamellipodia. VASP can be phosphorylated by PKA and PKG; phosphorylation disrupts protein associations. VASP has been shown to interact with PKA, PKG, actin, vinculin, zyxin, profilin, F-actin, and c-abl. The Poly6156 antibody recognizes the C-terminal region of human and mouse VASP and has been shown to be useful for Western blotting.