Purified anti-TIF1beta (KAP-1, TRIM28)

TIFbeta (transcription intermediary factor 1-beta) is an 88 kD member of the tripartite motif family. This protein contains three zinc binding domains, a RING domain, a B-box type 1 and type 2 domain, and a coiled-coil region. TIFbeta is found in the nucleus and associates with specific chromatin regions. This protein forms a complex with KRAB-domain transcription factors and recruits setdbl to histone 3 to increase KRAB-mediated transcriptional repression. TIF1beta has been reported to interact with setdbl and cbx3 proteins. Studies using knockout mice reveal the important function of TIF1beta in regulating genomic imprinting, T cell activation, and T cell tolerance.

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SPECIFICATIONS

Catalog Number

619301

Size

25 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

20A1

Gene Id

10155

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microg per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store at 4C.

Alternative Names

Transcription intermediary factor 1-beta, KRAB-associated protein

Regulatory Status

RUO