Purified anti-TCF1 (TCF7)

TCF1 is the first identified member of the T-cell-specific transcription factor family. It plays an important role in T cell development and differentiation. TCF1 is inactivated by association with the transcriptional repressor TLE proteins. During Wnt signaling, the transcriptional coactivator CTNNB1 accumulates and, in turn, replaces the transcriptional repressor associated with TCF1. Interaction with CTNNB1 results in transactivation of TCF1 target genes. Deletion of TCF1 causes massive apoptosis of double positive thymocyte, suggesting that TCF1 is required for thymocyte survival during T cell development. In addition to its function in thymus, TCF1 promotes T cell differentiation to Th2 cells in the periphery through transcriptional activation of GATA3.

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SPECIFICATIONS

Catalog Number

655202

Size

100 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum

Clone

7F11A10

Antigen

Partial TCF1 recombinant protein (116-334 aa)

Gene Id

6932

Isotype

Mouse IgG1, kappa

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.1 - 0.5 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

T-cell-specific transcription factor 1 (TCF-1), transcription factor 7 (TCF-7)

Regulatory Status

RUO