Purified anti-Stathmin/Op18 Phospho (Ser16)

Stathmin/Op18 is a 21 - 23 kD member of the Stathmin family. This protein is localized in the cytoplasm and becomes nuclear during the S/G2 phase of the cell cycle. Stathmin/Op18 acts as a microtubule destabilizer in mitotic spindle regulation and sequesters tubulin dimers into assembly-incompetent complexes. This protein participates as an intracellular relay integrating regulatory signals of the cellular environment and has been shown to be involved in megakaryocyte polyploidization. Stathmin/Op18 can be phosphorylated in response to heat; Ser62 phosphorylation reduces tubulin binding ability. This protein can also be modified by acetylation. Stathmin/Op18 has been shown to interact with tubulin, KIST, CaM kinase II and IV, Cdc2, MAPK, and Cdk1. The Poly6202 antibody recognizes human phosphorylated stathmin/Op18 (Ser16) and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

620202

Size

200 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6202

Antigen

Modified peptide

Gene Id

3925

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

Oncoprotein 18

Regulatory Status

RUO