Purified anti-SOX2

This rabbit polyclonal antibody recognizes human SOX2, also known as SRY (sex determining region Y)-box 2 and ANOP3. SOX2 is a nuclear protein with a predicted molecular weight of 34 kD. SOX2 belongs to the SOX (SRY-box containing gene) gene family which encodes a group of transcription factors defined by the conserved high motility group (HMG) DNA-binding domain. They are involved in the regulation of embryonic development and in the determination of cell fate. Defects in SOX2 are a cause of true or primary anophthalmos, also called anophthalmia or ANOP3. Anophthalmos is a developmental defect characterized by complete absence of the eyes (rare) or by the presence of vestigial eyes.