Purified anti-SOCS3

The SOCS3 (suppressor of cytokine signaling-3) protein is a 25 kD cytoplasmic protein that contains a SOCS box and an SH2 domain. SOCS3 has been shown to be involved the negative regulation of cytokine signaling via JAK/STAT pathway. SOCS3 has been shown to inhibit IL-2, IL-3, IL-4, IL-6, erythropoietin, prolactin, and growth hormone. SOCS3 has also been shown to regulate erythropoiesis in the fetal liver. SOCS3 is induced induced by inflammation, erythropoietin, GM-CSF, IL-10, and IFN-gamma. SOCS3 can be modified by JAK phophorylation which destabilizes the protein and ubiquitination which targets for destruction by the proteosome. SOCS3 has been shown to interact with the IGF-1 receptor, insulin receptor, gp130 receptor, erythropoietin receptor, leptin receptor, LIF receptor, JAK2, and elongin C. The SOC-25 monoclonal antibody recognizes human and mouse SOCS3 and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

626601

Size

25 microg

Applications

WB

Hosts

Mouse

Reactivities

Hum, Mouse

Clone

SOC-25

Antigen

Full-length SOCS3 recombinant protein

Gene Id

9021

Isotype

Mouse IgG2b

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5 microg per 5 ml antibody dilution buffer (1:500 dilution) for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at 4C.

Alternative Names

Suppressor of cytokine signaling-3

Regulatory Status

RUO