Purified anti-RORg

RORgamma (Retinoid-related orphan receptor gamma) belongs to the nuclear hormone receptor family, NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. RORgamma has two isoforms: gamma1 and gamma2 (also referred to as RORgammat). The RORgammat differs from the RORgamma1 isoform in that it lacks the amino terminus of RORgamma1. RORgamma1 contains 516 amino acids and RORgammat contains 495 amino acids. RORgamma1 has a molecular weight of approximately 58 kD. RORgamma1 is highly expressed in thymus, kidney, liver, muscle, and brown fat but not in white fat tissue. RORgammat is specifically expressed in only two cell populations, DP thymocytes and lymphoid tissue inducers (LTi). RORgamma plays a critical role in control apoptosis during thymopoiesis and T cell homeostasis. RORgammat is to regulate TCRalpha repertoire by virtue of its positive regulatory role on Bcl-x expression. RORgamma is essential for lymph nodes and Peyers patch development.

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SPECIFICATIONS

Catalog Number

646502

Size

100 microg

Applications

WB

Reactivities

Mouse

Clone

RORg2

Antigen

Mouse RORgamma

Gene Id

19885

Isotype

Armenian Hamster IgG

Clonality

Monoclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 1-2 microg per lane. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

4 C

Concentration

0.5 mg/ml

Shipping Temp

Ambient RT

Storage Buffer

The antibody solution should be stored undiluted at 4C.

Alternative Names

RORc, Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma

Regulatory Status

RUO