Purified anti-RARa

RARalpha (retinoic acid receptor alpha) is a 51 kD member of the nuclear hormone receptor family, NR1 subfamily. This nuclear protein contains modulating, DNA-binding, and steroid binding domains, and has been reported to have multiple isoforms. RARalpha is a nuclear receptor for retinoic acid that controls cell function by regulating gene expression and inducing profound effects on vertebrate development, acting as a morphogen and powerful teratogen. RARalpha is increased by protein kinase C stimulation, and estrogen; decreased at G0/G1 to S phase of cell cycle and in lymphocytes by cellular activation. RARalpha can be modified by phosphorylation and has been shown to interact with NCOA3 and NCOA6 co-activators leading to strong increases in the transcription of target genes. The Poly6168 antibody recognizes the N-terminal region of human RARalpha and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

616801

Size

50 microl

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6168

Antigen

Recombinant (partial), N-terminal amino acids 1-100

Gene Id

5914

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

Retinoic acid receptor alpha, RAR alpha

Regulatory Status

RUO