Purified anti-PLCgamma-1 Phosphorylated (Tyr783)

PLCgamma-1 is a ubiquitously expressed isozyme that is activated by phosphorylation of tyrosine 783. It plays important roles in mammalian growth and development, proliferation, differentiation, signal transduction, endocytosis, cytoskeletal reorganization, and activation of ion channels. In the brain, PLCgamma-1 is highly expressed and participates in brain development and synaptic transmission. Abnormal expression and activation of PLCgamma-1 is associated with various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Research in zebrafish also suggests its important roles in the maturation of granulocytes.

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SPECIFICATIONS

Catalog Number

656202

Size

200 microl

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Clone

Poly6562

Antigen

KLH conjugated modified synthetic peptide

Gene Id

5335

Isotype

Rabbit Polyclonal IgG

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.5 - 4.0 microg per ml. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store undiluted at -20C.

Alternative Names

PLCG1, PLC Gamma1, PLCg 1, NCKAP3

Regulatory Status

RUO