Purified anti-PARC (H7AP1)

The PARC protein, also known as p53-associated parkin-like cytoplasmic protein and UbcH7 associated protein 1, is a large (>250 kD) ubiquitously expressed cytoplasmic protein that contains a cullin domain and signature RING-IBR (in-between ring finger domain)-RING domains. PARC is thought to serve as a cytoplasmic anchor in p53-associated complexes thought to be critical in controlling p53 subcellular localization and function. These large complexes that contain PARC, p53 and other associated proteins are approximately 1 MD in non-stressed cells. The PARC protein has been shown to interact with a number of proteins including p53, UBCH8, ubiquitin conjugating enzyme E2G2, and ubiquitin conjugating enzyme E2L3. The P069 monoclonal antibody recognizes human PARC and has been shown to be useful for Western blotting.