Purified anti-p63 (deltaN)

p63 (deltaN) is a member of the p53 family. This protein has multiple isoforms TA p63-alpha, -beta, gamma, deltaN p63-alpha, -beta, and -gamma. The molecular weights of the p63 isoforms alpha=66 kD, beta=52 kD, and gamma=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. deltaN isoforms are antagonistic to p53; TA isoforms can transactivate p53 targets. The p63 deltaN isoforms repress TA isoforms; mutant p53 abrogates p63 transactivation. This protein interacts with p53, p73, and the various TA- and deltaN isoforms. The Poly6190 antibody recognizes human p63 deltaN isoforms and has been shown to be useful for Western blotting.

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SPECIFICATIONS

Catalog Number

619001

Size

50 microl

Applications

IF, WB

Hosts

Rabbit

Clone

Poly6190

Antigen

Modified peptide

Gene Id

8626

Isotype

Rabbit Polyclonal

Clonality

Polyclonal

Dilutions

Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 microl per 5 ml antibody dilution buffer for each mini-gel. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimal performance for each application.

Storage Temp

-20 C

Concentration

Shipping Temp

Ambient RT

Storage Buffer

Upon receipt, store frozen at -20 C.

Alternative Names

p63, Isoforms TA p63-alpha, -beta, -gamma, deltaN p63-alpha, -beta, -gamma

Regulatory Status

RUO